Pharmacokinetic research studies with clindamycin have shown no medically vital distinctions in between senior as well as young topics with normal hepatic function as well as typical (age-adjusted) kidney function after oral or intravenous administration.

Gastrointestinal: Abdominal discomfort, pseudomembranous colitis, esophagitis, nausea, puking, and looseness of the bowels (see WARNING box). The start of pseudomembranous colitis signs and symptoms may take place during or after anti-bacterial treatment (view WARNINGS). Esophageal abscess has actually been stated.

Hypersensitivity Reactions: Generalized light to modest morbilliform-like (maculopapular) skin rashes are the most regularly reported adverse reactions. Vesiculobullous rashes, in addition to urticaria, have been observed during drug therapy. Severe skin responses such as Toxic Epidermal Necrolysis, some with fatal end result, have actually been stated (See WARNINGS). Cases of Acute Generalized Exanthematous Pustulosis (AGEP), erythema multiforme, some looking like Stevens-Johnson disorder, and also anaphylactoid reactions have likewise been stated.

Kidney: Although no direct partnership of clindamycin to kidney damages has actually been set up, kidney disorder as evidenced by proteinuria, azotemia, and/or oliguria has actually been observed.

Hematopoietic: Transient neutropenia (leukopenia) as well as eosinophilia have actually been reported. Records of agranulocytosis and also thrombocytopenia have actually been made. No direct etiologic connection to concurrent clindamycin treatment might be made in any one of the prior.

Considerable death was observed in mice at an intravenous dose of 855 mg/kg and in rats at a oral or subcutaneous dosage of about 2618 mg/kg. In the mice, convulsions and also depression were noted.

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